To estimate the incidence of Contrast-Induced Nephropathy (CIN) among Diabetics and evaluate the association of gender and the risk of CIN. In addition, to study the relation of diabetes mellitus and hypertension in the development of CIN. This was a retrospective cohort study performed at King Khalid University Hospital (KKUH), Riyadh, Kingdom of Saudi Arabia. We included 410 diabetic patients undergoing CT Contrast. Data has been collected from KKUH medical records during 2018-2020, which was done by comparing the baseline and post-contrast serum creatinine levels. The incidence of Contrast-induced nephropathy was 13.9%, and this represents 57 patients of 410. Out of those 57 patients, 77.19% (44 of 57) were hypertensive, 78.94% (45 of 57) were comorbid. The incidence of Contrast-induced nephropathy among females was 14.9% (31 of 208), and The incidence of Contrast-induced nephropathy among males was 12.9% (26 of 202). The incidence of Contrast-induced nephropathy was 13.9%. A lot of factors can influence the incidence of CIN. Being hypertensive increases the risk of CIN by 2.332 times more than not being hypertensive. Diabetic patients must be monitored carefully, and special measures should be taken.